Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy

摘要

In summary, we have developed a new temperature/pH responsive intra-intercellular NP delivery system, which was composed of biopolymer-based nanogels with carbon nanotubes cores and crosslinked PNIPAAm-PEG shell. The obtained nanogels presented temperature/pH sensitive reversible swelling-shrinking capability, which was believed to be able to facilitate the tumor vessel penetration and tumor cells retention under NIR irradiation in-vivo. The in-vivo evaluation exhibited a safe and high efficient therapeutic effect. We believe that this strategy will provide the idea to explore more intelligent drug delivery nanoplatforms for high efficient tumor targeting therapy.