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uPAR-TARGETED PHOTOTHERMAL OPTICAL PROBES FOR PHOTOTHERMAL THERAPY
uPAR-TARGETED PHOTOTHERMAL OPTICAL PROBES FOR PHOTOTHERMAL THERAPY
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机译:用于光热疗法的UPAR靶向的光热光学探针
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摘要
The present invention relates to tumor-targeted probes for use as medicaments and for use in treatment of cancer and to methods of treatment wherein such probes are used. The probes consist of a light-absorbing molecule linked directly or via a spacer to a peptide targeting the urokinase-type plasminogen activator receptor (uPAR). When irradiating the light-absorbing molecule of the probe with laser beams from an external source heat will be released locally to tumor cells expressing uPAR resulting in tumor ablation.
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