Tunable Antibacterial Gellan Hydrogels for Burn Wounds

摘要

We have developed a unique antibiotic delivery system using entirely FDA approved materials and without covalent crosslinking modifications. Vancomycin is successfully released above MIC for varying durations of time as a result of the inclusion of drug-loaded activated carbon particles. Our hydrogel system eliminates the need for daily reapplication, and has the potential to improve patient compliance. We are currently testing in vivo efficacy of our hydrogels in a murine burn infection model.