Minimally invasive needle-free bubble injector for gene therapy

摘要

We have successfully developed minimally-invasive needle-free bubble-injector designed for usage in air. The novelty is that minimally-invasiveness of injection whose resolution is less than 10 m, and hence cellular-scale and painless injection can be obtained. The bubble-injector can be employed to any kind of materials with wide range of hardness using strong impact of cavitation. The fine adjustment of invasiveness of injection can be controlled by the number of applied electric pulses. The developed injector can be used for wide range of biomedical study, especially in gene therapy.