This paper reports a monolithic microfluidic device capable of complete blood constituent enumeration from raw blood. On-chip sample processing (e.g. dilution, lysis, and filtration) and downstream single cell measurement were fully integrated to enable sample preparation and single cell analysis from whole blood on a single device. The device consists of two parallel sub-systems that perform sample processing and electrical impedance measurements for measuring RBC and WBC parameters. Experimental characterization of patient blood samples validated the system's capability for performing on-chip raw blood processing and measurement.
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