Tracking of unlabeled single virions in a nano-fluidic optical fiber

摘要

We present a tracking method based on elastic light scattering, which utilizes the strongly confined optical mode and low residual scattering of light in a nano-fluidic silica fiber. Using this method, we have tracked the diffusion of unlabeled 26-nm cowpea chlorotic mottle virions and 20-nm latex particles at rates of over 2 kHz.