In-vitro Evaluation of Three Dimensional Single Walled Carbon Nanotube Composites for Bone Tissue Engineering

摘要

Our results demonstrated that SWCNT/PLAGA composites promoted cell adhesion, growth, and survival, and have a higher mechanical strength and cell proliferation rate than PLAGA composites. The findings from this study demonstrated the potential of SWCNT/PLAGA composites for BTE and musculoskeletal regeneration. In order to for this novel SWCNT/PLAGA to serve as a functional bone substitute, future studies must evaluate the porosity of these composites as well as in-vivo biocompatibility and toxicity using a rat model, and the regenerative capacity of a non-union bone defect using a rabbit model. Until now, a 3-D SWCNT/PLAGA composite was unavailable. The 3-D design of the SWCNT/PLAGA composite allows for greater porosity and provides a means of fixation in a large bone defect. Composites capable of promoting bone growth in a large bone defect will have a significant impact on bone regeneration and will allow greater functional recovery in injured patients.