We successfully fabricated DPV-loaded nanofibers (DPV-NF) and ETR-loaded nanoparticles (ETR-NP) using a pH-sensitive PMAA-co-PMMA copolymer that undergoes a gel-to-solution phase transition in response to alkaline pH. Under acidic conditions, nanocarriers remained intact and result in sustained release of DPV and ETR. However, under alkaline conditions, the nanocarriers rapidly dissolve and burst release DPV or ETR. Although pH modulated the same burst or sustained release profile from either carrier, nanoparticle carriers exhibited much faster release kinetics compared to nanofibers. These materials may be useful for delivery of other ARV drugs or drug combinations with programmable release kinetics.
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