Construction of iPSC-Derived 3D-Cardiac Muscle Tissues Using Cell-Accumulation Technique for Pharmaceutical Applications

摘要

We demonstrated the construction of 3-9L rCM tissues. They showed successful stimulation of beating rete in response to adrenergic drug. Furthermore, we succeeded to fabricate 7L-iPSC-derived 3D-cardiac muscle tissues. This approach would be useful for tailor-made drug screenings and toxicological evaluations. In the conference, we will present functional data of 3D-cardiac tissues including iPSC-derived tissues. These reconstructed 3D-cardiac tissues will be also useful for tissue engineering application, such as ischemic diseases.