Transplant tolerance to minor antigen mismatched bone marrow grafts using PLG particles

摘要

The CD4 male-specific Dby epitope induces tolerance to minor HY antigen mismatched bone marrow grafts, both when coupled to the surface of PLG particles and encapsulated within PLG particles. The percentage of engrafting donor bone marrow cells in tolerized recipients exceeded 50% in several animals, and a single particle dose on Day +1 was sufficient for tolerance. Conversely, the CD8 Uty epitope did not induce tolerance, indicating that CD4 T cells are the primary mediator of graft rejection in this model. Future studies will address transplant tolerance in a fully MHC mismatched allogeneic model, where the donor antigens are numerous and unidentified. Using PLG particles as a platform for inducing tolerance in minor HY antigen mismatched bone marrow transplantation is a key step in developing a translatable, donor-specific tolerance strategy for modern transplantation procedures.