Programmable Nucleic Acid Polymerization for Nanoparticle-Mediated Imaging of the ECM

摘要

The bifunctional nanoparticles can play dual roles of recognizing target ECM components and inducing signal amplification in the ECM via DNA polymerization. Therefore, nanoparticle-programmed DNA polymerization holds great potential for in vivo tissue imaging. Moreover, it is promising to achieve single- or multiple-modality imaging with signal amplification by using two DNA monomers with identical or different imaging agents. This concept is currently under investigation with animal models.