Peptide-functionalized polymers for bone targeted drug delivery systems

摘要

RAFT polymerizations were used to controllably produce peptide-functionalized polymers with differing affinity towards TRAP, a useful homing target for drug delivery to bone. Incorporation of multiple TBP moieties provided targeted binding of polymer to TRAP even greater than TBP alone. Finally, preliminary experiments in mice show localization of targeted polymer with resorption surfaces, illustrating the potential for these polymers to be used for highly tunable bone targeted drug delivery in vivo. Future work includes more thorough and sophisticated pharmacokinetics and biodistribution analyses of targeted polymers and inclusion of bone-acting drugs to initiate bone regeneration specifically at the sites of bone resorption.