Reorganization and termination of a spiral wave reentry following a defibrillation shock

摘要

This modeling study examines the behavior of a spiral wave reentry during and after a defibrillation shock in tissue slices of various dimensions. The tissue is represented as a two-dimensional anisotropic bidomain with modified Beeler-Reuter kinetics. Stable reentry is induced by means of cross-stimulation. The defibrillation shock is delivered via extracellular line or point electrodes located at the opposite tissue borders. Shocks delivered through line electrodes were less successful in extinguishing the rotor. The advantage of the shocks administered via the point electrodes in terminating the reentrant circuit is attributed to their ability to generate interelectrode regions of depolarization.