Leading to Long-Term Nonprogressor via Gradual Reduction of Drug Dose with Immune Dynamics Strongly Dependant on Target Cells

摘要

For a HIV dynamic model with immune system which strongly depends on the HIV target cells, we apply a recently proposed drug scheduling scheme: gradual reduction of drug dose. The feasibility of this scheme is analysed rigorously. By means of this method, the HIV patient is steered to an equilibrium condition known as long-term nonprogressor, which corresponds to an infected status not developing the symptoms of AIDS.