Potential Driver Genes Regulated by OncomiRNA Are Associated with Druggability in Pan-Negative Melanoma

摘要

OncomiRNAs (oncomiRs) are small regulatory microRNAs (miRNAs) that play an important role in tumor formation and progression. These oncomiRs are found to regulate different types of tumor by targeting a large set of cancer driver genes (including oncogenes and tumor suppressor genes). In the present work, we have developed a pipeline for the identification of frequently occurring and clinically relevant driver genes in pan-negative melanoma (absence of mutations in BRAF (affecting V600), NRAS (G12, G13, and Q61), KIT (W557, V559, L576, K642, D816), GNAQ (Q209), and GNA11 (Q209) by integrating oncomiRs regulated genes and frequently mutated genes in melanoma pan-negative samples. The preliminary experience has identified 28 potential driver genes that are regulated by oncomiRs, of which 25 genes are associated with drugs, 3 differentially expressed genes are associated with metastasis. This analysis provides a method to mine clinically relevant driver genes in pan-negative melanomas.