Design, Fabrication, and Characterization of Microscale Bicuspid Valves 3D Printed in Biocompatible Hydrogels

摘要

Conclusions: This work demonstrates the feasibility of constructing computational FSI models to investigate structure function relationships in microscale bicuspid valves along with the fabrication valve structures from biocompatible hydrogels using our new pSLA system that function as dynamic fluidic diodes. Flow patterns through computational models corresponded with preliminary experimental models, though more advanced particle tracking techniques are needed for future analysis. This work represents a preliminary step towards the investigation of structure-function relationships within venous valves in vitro, as a means to guide treatment of CVI in patients along with the development of microscale valves for the incorporation into engineered tissues.