Antioxidant nanoparticles for inhibition of inflammation-mediated rheumatoid arthritis

摘要

PTx loaded PEG-PLA nanoparticles served to reduce a marker oxidative stress and replenish total antioxidant content in the organs of mice in an arthritic mouse model. Fluorescent imaging analysis of the organs indicates significant accumulation over a 5 day period as compared to control mice. Most importantly, imaging analysis suggests higher accumulation of nanoparticles in the inflamed joints possibly due in part to enhanced permeation and disruption of vasculature in the limbs. These nanoparticles also served to significantly reduce the levels of oxidized protein in the limbs, a marker of downstream damage due to inflammation. This preliminary data serves as a potential therapeutic delivery system for the treatment of rheumatoid arthritis and the accompanying inflammation-mediated damage caused.