Size Matters: Effects of PLGA-Microsphere Size in Injectable CPC/PLGA on Bone Formation

摘要

This study demonstrates that PLGA-microsphere dimensions of ~25μm are sufficient for bone ingrowth and allow significantly more bone formation compared to ～100 μm PLGA-microspheres. Further, the histological data demonstrate that PLGA-microsphere dimensions provide a tool to control bone formation for injectable CPC/PLGA bone substitute materials.