Application of genetically engineered Salmonella typhimurium as tumor targeting agents

摘要

Some attenuated bacteria have been studied as viable tumor-targeting agents. Among them, Salmonella typhimurium carrying many advantages such as growth in both of aerobic and anaerobic conditions, various attenuated virulent strains, universal genetic engineering tools, and the clarified full genome sequences has been studied the most up to now. In this paper, we review recent progresses of tumor treatment using this bacterium.