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The effects of synthetic Azurocidin peptide analogue on Staphylococcus aureus bacterium

机译:合成硫杂菌素肽类似物对金黄色葡萄球菌的影响

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Antibiotics are commonly used as anti-infection drugs. However, the rising of microbial resistance to antibiotics imposes a major challenge to their widespread applications. Hence, there is a growing need to find alternative drugs to eradicate the microbial resistance arising from the excessive use of antibiotics. Antimicrobial peptides (AMPs) are natural defence molecules found in human body. These AMP are present virtually in all life forms where they act as the first line defence agents against invading pathogens. Published studies [1] [2] suggest the possible use of AMPs as alternative anti-infective drugs. In this study we evaluated the anti-microbial activity of a synthetic Azurocidin peptide analogue and compared its efficacy with the native natural antimicrobial peptide Azurocidin. The Resonant Recognition Model (RRM) was employed here to computationally design a short Azurocidin peptide analogue, Azu-RRM. According to the RRM, this de novo designed peptide analogue will mimic and exhibit the activity of the natural Azurocidin (Azu) protein. Within this study the antimicrobial activity of Azu-RRM was investigated on Staphylococcus aureus (ATCC 25923) bacterium. The results obtained reveal that the synthetic peptide analogue affected the growth of this gram positive bacterium. The findings also showed that the Azu-RRM is exhibiting the anti-microbial effects on the growth of the studied bacteria comparable with the suppressing effects induced by the natural Azu protein.
机译:抗生素通常用作抗感染药物。然而,微生物抗性对抗生素的升高对其广泛的应用施加了重大挑战。因此,越来越需要寻找替代药物来消除从过量使用抗生素而产生的微生物抗性。抗微生物肽(AMPs)是人体中发现的天然防御分子。这些放大器实际上存在于所有生命形式中,他们充当针对入侵病原体的第一线防御药剂。已发表的研究 [1] [2] 表明可能使用放大器作为替代抗感染药物。在该研究中,我们评估了合成硫脲肽肽类似物的抗微生物活性,并将其与天然天然抗微生物肽硫脲的功效进行了比较。这里使用共振识别模型(RRM)来计算设计短的硫脲肽类似物,Azu-RRM。根据RRM,这种De Novo设计的肽类似物将模拟并表现出天然硫酸脲(Azu)蛋白的活性。在本研究中,研究了金黄色葡萄球菌(ATCC 25923)细菌的抗菌活性Azu-RRM。得到的结果表明,合成肽类似物影响了该革兰氏阳性细菌的生长。结果还表明,Azu-rrm表现出对研究细菌的生长的抗微生物作用与天然Azu蛋白诱导的抑制作用相当。

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