In vitro and in vivo studies on Mg-Sr binary alloy system developed as a new kind of bone anabolic and biodegradable metals

摘要

The effect of Sr content in Mg was proved to be dose dependent with respect to mechanical and corrosion properties and the optimal Sr amount was 2wt.%. The in vitro cell experiment indicated as-rolled Mg-2Sr alloy exhibited Grade I cytotoxicity and improved ALP activity. The in vivo investigation results showed that as-rolled Mg-2Sr alloy gradually degraded within bone marrow cavity and the degradation process did not induce adverse effect during 4 weeks implantation. All in all, as-rolled Mg-2Sr alloy seems to be promising as orthopedic biodegradable materials.