Contribution of Glutathione Redox Imbalance to Bioenergetics Status in Alzheimer Mouse Model

摘要

The data from this study demonstrated that altered GSH redox balance in specific brain regions is age- and genotype-linked in the transgenic model of AD (B6.Cg). Collectively, the data show that GSH redox imbalance and subsequent S-glutathionylation of proteins are early events, and provides a time line for when these redox changes occur during AD progression.