The examination of extracellular matrix proteoglycans and growth factors in decellularized tendon slices

摘要

The current study indicates that the ECM proteoglycans and growth factors could be well preserved in the decellualrized tendon slices. The sliced tendon scaffold decellularized by repetitive freeze/thaw in combination with nuclease treatment 12h may not only be used as an excellent bioscaffold for tissue engineered tendons with the variability in size and strength and the feasibility of allowing for much more cellular seeding or ingrowth than an intact tendon, but also may work well as a biological healing material for surgical repair due to its well-preserved extracellular bioactive factors.