Microfabrication of Porous Silicon Disks for Multistage Drug Delivery

摘要

Rational designed discoidal pSi particles were fabricated by the help of photolithographic process. The geometry effect of pSi disks on the in-vivo biodistribution was confirmed and optimized. These biodegradable pSi disks were used as stage 1 vectors in several MDS systems, and demonstrated suprior theropeutic efficacy.