Therapeutic Silencing of Hypoxia-Inducible Factor-1α Using Mixed Micelle Particles Inhibits Prostate Cancer Cell Growth under Hypoxia

摘要

This study indicated that targeting HIF-1α with MMP_(siHIF) could induce HIF-1α silencing and resulted in cell proliferation inhibition under the in vitro mimic hypoxic condition. The underlying concept of targeting a specific protein expressed in tumor microenvironment by nanoparticles might provide a novel approach to cancer therapy.