A Gelatin-Based Hydrogel with p-Cyclodextrin Crosslinker for Controlled Drug Release

摘要

A novel gelatin hydrogel was prepared by using 1, 1'-carbonyldiimidazole (CDI) activated β-cyclodextrin (P-CD) as crosslinker. The hydrogel was characterized by 'H NMR spectroscopy, in vitro degradation, MTT assay, drug loading/release study with anticancer drug of methotrexate (MTX). Degradation and drug loading/release properties of the hydrogel can be controlled by changing the crosslinker content. In vitro cytotoxicity test indicated nontoxicity of this material to L929 cells (mouse connective tissue fibroblast), showing that this new crosslinked gelatin hydrogel is biocompatible and can be used as a potential drug carrier in human body.