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Injectable Absorbable Liquid Gel-Forming Systems for Localized Delivery of Therapeutic Agents

机译:用于局部递送治疗剂的可注射吸收性液体凝胶形成系统

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This polymeric system has demonstrated full modularity and the major controlling variables have been identified through extensive in vitro testing. This control can be achieved through a variety of ways including introduction of polymeric additives and end group modification. Future work with this system will include in vivo testing and correlation to in vitro models. The end goal entails a fully customizable platform technology that inputs drug characteristics and desired release specifications and outputs the required polymeric system, which could serve as a delivery vehicle for bioactive agents such as antibiotics, peptides, hormones, and antineoplastics among others.
机译:该聚合物系统已显示出完全的模块性,并且主要的控制变量已通过广泛的体外测试确定。该控制可通过多种方式实现,包括引入聚合物添加剂和端基改性。该系统的未来工作将包括体内测试以及与体外模型的相关性。最终目标需要一种完全可定制的平台技术,该技术可以输入药物特性和所需的释放规格并输出所需的聚合物系统,该系统可以用作生物活性剂(例如抗生素,肽,激素和抗肿瘤药)的运输工具。

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