Absorbable Synthetic Bone Wax for the Localized Delivery of Therapeutic Agents

摘要

Of the two methods investigated for the preparation of bone wax-drug formulations, only cold-working resulted in a completely stable bone wax-drug formulation over 7 days. This novel material shows great promise, not only as a bioresorbable substitute for commercially available bone wax, but also as a vehicle to release prophylactic agents for the prevention of SWI. Future studies will investigate the drug stability for cold-worked formulations over an extended time frame.