Creation of a collagen scaffold integrating mesenchymal stem cells and microencapsulated peptides for use in wound healing.

摘要

Previous work shows both epithelial cells and BMSCs primed on liquid collagen gels undergo EMT, physically manipulating gels. Here a 2.5% solid matrix is shown to undergo a similar process, indicating BMSCs can be "primed" to interact with each other in a controlled pattern. Microencapsulated aCTl releases within 24 hours and sustains release for -72 hours making this ideal for use in wound healing studies where the inflammatory and granulation phases of tissue healing are occurring in this time frame.