Heparin-decorated, Hyaluronic Acid-based Hydrogel Particles for the Controlled Release of Bone Morphogenetic Protein 2

摘要

Hyaluronic acid-based hydrogel particles containing covalently immobilized heparin were successfully synthesized via inverse emulsion polymerization. The controlled release of BMP-2 combined with the inductive role of HA in chondrogenesis make the current system very promising for growth factor therapy. In vivo assessment of the hybrid BMP-2 delivery system is currently underway.