Translation of Antibody-Polysaccharide Conjugates to Treating Burns in the Clinic

摘要

We hypothesize that conjugation of cytokine-neutralizing antibodies to high molecular weight polysaccharides localizes the antibodies to the site of application due to the slow polysaccharide diffusion. Local cytokine neutralization could be an important strategy for treating a broad range of conditions with strong underlying inflammatory components, including burns, chronic wounds, and osteoarthritis. This presentation will discuss the biochemical basis for the effects of these biomaterials and discuss efforts at translation of the technology into the clinic, including intellectual property, regulatory approval, fund-raising, and partnering with established producers of anti-TNF-a.