机译:抗体药物缀合物的翻译在小鼠实验肿瘤到临床中的疗效:一种PK / PD方法
Department of Pharmacokinetics Dynamics and Metabolism Translational Research Group Pfizer Global;
Department of Pharmacokinetics Dynamics and Metabolism Translational Research Group Pfizer Global;
Oncology Research Unit Pfizer Global Research and Development Pearl River NY 10965 United States;
Department of Pharmacokinetics Dynamics and Metabolism Pfizer Global Research and Development;
Oncology Research Unit Pfizer Global Research and Development Pearl River NY 10965 United States;
Oncology Research Unit Pfizer Global Research and Development Pearl River NY 10965 United States;
Department of Pharmacokinetics Dynamics and Metabolism Translational Research Group Pfizer Global;
Department of Pharmacokinetics Dynamics and Metabolism Translational Research Group Pfizer Global;
Antibody drug conjugates; Pharmacodynamics; Pharmacokinetics; Prediction; Translation; Tumor regression; Xenograft;
机译:从小鼠实验肿瘤到临床的抗体药物偶联物功效的转换:PK / PD方法
机译:定量系统药理学模型既捕获非临床PK / PD,促进屏蔽肿瘤活化的CD71抗体药物缀合物的临床翻译。
机译:在抗体药物缀合物功效中建立体外体内相关性:PK / PD建模方法
机译:使用肽 - 接头 - 药物分析物进行抗体缀合药物测量的新型PK测定的方法开发
机译:使用单细胞成像和多尺度建模改善抗体药物结合的肿瘤分布和功效
机译:PK-PD建模和基于仿真的策略在抗体-药物缀合物临床翻译中的应用:曲妥珠单抗Emtansine(T-DM1)的案例研究
机译:解开羧基酯酶1c和抗体 - 药物缀合物SYD985之间的相互作用:通过使用CES1C敲除小鼠改善平移PK / PD