Prediction of Combinatorial Protein-Protein Interaction Networks from Expression Data Using Statistics on Conditional Probability

摘要

In this paper we propose a method to retrieve combinatorial protein-protein interaction to predict the interaction networks from protein expression data based on statistics on conditional probability. Our method retrieves the combinations of three proteins A, B and C which include combinatorial effects among them. The combinatorial effect considered in this paper does not include the "sole effect" between two proteins A-C or B-C, so that we can retrieve the combinatorial effect which appears only when proteins A, B and C get together. We evaluate our method with a real protein expression data set and obtain several combinations of three proteins in which protein-protein interactions are prediced.