Nanofibers-based DDS electrospun from co-dissolving solutions of Eudragit L-100 and diclofenac sodium

摘要

The paper presents the preparation and characterization of nanofibers-based drug delivery systems (DDS) electrospun from co-dissolving solutions of Eudragit L100 and diclofenac sodium (DS). Eudragit L-100 and DS could well co-dissolve in a mixed solvent of methanol and dimethylacetamide (DMAc) with a volume ratio of 6 to 1 for preparing the spinning solutions. Scanning electron microscope (SEM) was carried out to observe the morphology of the nanofibers. Fourier-transform infrared (FTIR) was conducted to clarify the interactions between the drug and the matrix polymer. Drug release profiles were investigated using in vitro dissolution tests. Results from SEM showed that the drug was distributed evenly in Eudragit L-100 nanofibers. FT-IR results demonstrated that the main interactions between Eudragit L-100 and DS were hydrogen bonding. The in vitro dissolution tests showed that drug release rate from drug-loaded nanofibers mainly depended on the pH value of the dissolution media. Drug-loaded Eudragit L-100 nanofibers could be promising for preparing colon-targeted DDS.