The effect of polymer and CaCl2 concentration on sulfasalazine release from alginate-N,Ocarboxymethylchitosan beads

摘要

At present study, to effectively deliver sulfasalazine(SA) to the colon, pH sensitive polymeric beads wereprepared by ionic gelation of alginate-N,O-carboxymethylchitosan (NOCC) blend solution in CaCl2 solution. A 32full factorial design was employed to evaluate the effectof polymer and CaCl2 concentration on the drug releasebehavior of the beads in simulated gastrointestinal tractfluid. Both factors had significant effect on drug releasebehavior of carriers. Increasing polymer and CaCl2concentration resulted in decreased rate of swelling andSA release. No burst effect for drug release was observed.Based on these results, the alginate-NOCC beads preparedwith high polymer concentration are potentially suitablepolymeric carrier for colon-specific delivery ofsulfasalazine.