DRUG DOSAGE FORM CONTAINING A CORE HAVING AT LEAST TWO LAYERS, BOTH CONTAINING A POLYMER THAT FORMS MICROSCOPIC GEL BEADS UPON HYDRATION BUT ONLY ONE CONTAINS THE DRUG AND AN IMPERMEABLE, INSOLUBLE COATING CONTAINING APERTURES WHICH PROVIDE FOR THE HYDRATION AND RELEASE OF THE BEADS

摘要

A device is disclosed for the controlled delivery of a beneficial agent, the device consisting of (i) a core comprising at least two layers, wherein at least one layer comprises a beneficial agent and a polymer which forms microscopic gel beads upon hydration and at least one layer which comprises a polymer which forms microscopic gel beads upon hydration; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the microscopic gel beads.