Polypropylene Bio-CD: A novel photoluminescence based estimation of Glucose concentration with ultrasonic technology as an enabler

摘要

Flash-free micro patterns were embossed on polypropylene (PP) surfaces with ultrasonic heating for a biosensing lab-on-CD application. The embossing technique relied on a micro-cellular foamed substrate to absorb the displaced material during the embossing process for a zero mass transfer in far fields. The embossed features were designed to act as reservoirs, valves and reaction chambers to allow glucose levels to be measured in an unknown sample in a standard PC-CD player and thus termed 'Glucose Bio-CD'. Once embossed, the surface energy of the plastic substrate was chemically modified to make it hydrophilic. The surface energy was increased by 65.5% allowing the micro-fluidic devices to work properly. A front detection, photoluminescence (PL)-based sensing, using an organic light-emitting diode (OLED) as the excitation source, was used to estimate a glucose concentration. A relatively good correlation was observed between the glucose level and the PL.