Assessment of Novel Liquid Crystalline Materials in the Oral Controlled Delivery of Lipophilic Compounds

摘要

The absorption of a model lipophilic drug cinnarizine (CZ) after oral administration in rats has been shown to be significantly sustained when delivered in lipid based liquid crystalline formulations. Further mechanistic studies have revealed that the gastric retention and sensitivity of the formulation to lipase mediated digestion are key factors in controlling drug absorption.