Novel Multifunctional Polymeric Micelles for Targeted Drug Delivery

摘要

Multifunctional micelle-forming poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) copolymers bearing acetal group on the PEO and carboxyl side groups on the PCL were synthesized. The multifunctional polymer was used to attach Doxorubicin (DOX) to PCL and GRGDS to PEO. GRGDS-PEO-b-PCL-DOX micellar drug conjugates demonstrated higher cytotoxicity against B16-F10 cells than unmodified micelles.