Hypoxia-sensitive, Multifunctional Nanoparticles for Targeted Drug Delivery to Breast Cancer.

摘要

We obtained polymeric nanoparticles containing redox-sensitive moieties, which can be removed by chemically or enzymatically triggered reduction. Since the trimethyl lock-based functional groups undergo the triggered reduction to release a lactone and expose free hydrophilic functional groups, a class of trimethyl lock chemistry-based monomers were synthesized and polymerized to obtain biodegradable polymers for the redox-sensitive nanoparticles. Nanoparticles were prepared from the redox-sensitive biodegradable polymers via an emulsion method. The dynamic light scattering (DLS) experiment ensured that the size of nanoparticle significantly changed upon chemical reduction with sodium dithionite. In addition, the drug incorporated nanoparticles released the drug by the chemical reduction with sodium dithionite and the released hydrophobic drug was quantitatively profiled by HPLC. The nanoparticles that are able to respond to the triggered reduction would be promising as a drug delivery platform to target tumors.