Loading to solid lipid nanoparticles (SLN) improves cutaneous uptake of glucocorticoides widely varying in lipophilicity

机译：负载到固体脂质纳米颗粒（SLN）可以改善亲脂性差异很大的糖皮质激素的皮肤吸收

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In order to understand the interaction of SLN and the drug, SLN were loaded with prednicarbate (PC), betamethasone 17-valerate (BMV) and prednisolone (PD) and skin uptake was compared to commercial cream. SLN enhanced uptake up to 3.5-fold. The penetration was not related to the lipophilicity of the steroid.

机译：为了了解SLN与药物的相互作用，在SLN中加入了泼尼甲酸盐（PC），倍他米松17-戊酸酯（BMV）和泼尼松龙（PD），并将皮肤吸收量与市售乳膏进行了比较。 SLN的吸收提高了3.5倍。渗透率与类固醇的亲脂性无关。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.804-805|共2页
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Peggy Schlupp; Wolfgang Mehnert; Monika Schaefer-Korting;
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中图分类生物工程学（生物技术）;
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Loading to solid lipid nanoparticles (SLN) improves cutaneous uptake of glucocorticoides widely varying in lipophilicity

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