Site-specific Delivery of Oligonucleotides to Hepatocytes

机译：特异性寡核苷酸对肝细胞的寡核苷酸递送

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Galacosylated poly (ethylene glycol) (PEG-Gal) was conjugated to oligonucleotide (ODN) via an acid labile linkage of β-thiopropionate for its site-specific delivery to hepatocytes after systemic administration. A large percentage of ~(33)P-ODN-PEG-Gal was accumulated in the liver after systemic administration in rats, with highest uptake in the hepatocytes.

机译：通过β-硫代丙酸酸的酸不稳定连接到寡核苷酸（乙二醇）（乙二醇）（乙二醇）（乙二醇）与β-硫代丙酸酯的酸不合核键合缀合物，以在全身施用后至肝细胞的特异性递送至肝细胞。在大鼠的全身给药后，在肝脏后累积〜（33）p-ODN-PEG-GAL的大百分比累积，肝细胞最高吸收。

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《Controlled Release Society Annual Meeting and Exposition》|2007年||共2页
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Lin Zhu; Zhaoyang Ye; Kun Cheng; Duane D. Miller; Ram I. Mahato;
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中图分类生物工程学（生物技术）;
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1. Site-Specific Delivery of Oligonucleotides to Hepatocytes after Systemic Administration [J] . Lin Zhu, Zhaoyang Ye, Kun Cheng Bioconjugate Chemistry . 2008,第1期

机译：全身给药后寡核苷酸向肝细胞的位点特异性传递。
2. HPMA Polymer-Based Site-Specific Delivery of Oligonucleotides to Hepatic Stellate Cells [J] . Ningning Yang, Zhaoyang Ye, Feng Li Bioconjugate Chemistry . 2009,第2期

机译：HPMA基于聚合物的寡核苷酸向肝星状细胞的位点特异性传递。
3. Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes [J] . Prakash Thazha P., Yu Jinghua, Migawa Michael T., Journal of Medicinal Chemistry . 2016,第6期

机译：三天线N-乙酰半乳糖胺共轭反义寡核苷酸的靶向-肝细胞递送的全面结构-活性关系。
4. Site-specific Delivery of Oligonucleotides to Hepatocytes [C] . Lin Zhu, Zhaoyang Ye, Kun Cheng, Controlled Release Society Annual Meeting and Exposition . 2007

机译：寡核苷酸向肝细胞的位点特异性传递。
5. Site-specific synthesis and analysis of oligonucleotides containing the C8-deoxyguanosine adducts of the dietary mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. [D] . Elmquist, Carl Eric. 2005

机译：含有诱变剂2-氨基-3-甲基咪唑并[4,5-f]喹啉的C8-脱氧鸟苷加合物的寡核苷酸的定点合成和分析。
6. Site-specific Delivery of Oligonucleotides to Hepatocytes after Systemic Administration [O] . Lin Zhu, Zhaoyang Ye, Kun Cheng, -1

机译：全身给药后寡核苷酸向肝细胞的位点特异性传递。
7. Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice [O] . Thazha P. Prakash, Mark J. Graham, Jinghua Yu, 2014

机译：使用Triantennarary N-乙酰基半乳糖胺对肝细胞的靶向反义寡核苷酸的递送改善了小鼠的效力10倍

Site-specific Delivery of Oligonucleotides to Hepatocytes

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