Transdermal Permeation of Trimetazidine from Nerodilol-based HPMC Gel Drug ReservoirSystem Across Rat Epidermis

摘要

An HPMC gel drug reservoir system containing selected concentrations of nerodilol was prepared and subjected to in vitro permeation studies across rat epidermis. Nerodilol enhanced the flux of the drug across rat epidermis by about 1.96-times when compared to control. It is concluded from the study that HPMC gel drug reservoir containing 4% w/v of nerodilol showed optimal transdermal drug permeation.