Pharmacokinetics of a perivascular paclitaxel wrap formulation in a rat carotid artery model of restenosis

摘要

In vitro and in vivo studies wereconducted to assess whether paclitaxel release from1 and 20% loaded EVA films is well correlated toarterial tissue levels in rats after perivascularimplantation. The data confirm the efficacy ofpaclitaxel loaded EVA wraps in the rat carotid arterymodel of restenosis and demonstrate an apparentfirst order decrease in drug concentration in tissueand plasma after paclitaxel release from the wraphas stopped.