Solute Release from Biodegradable Hydrogel Composed of Polyethylene Glycol and Bacterial Polyglutamic Acid

摘要

Biodegradable hydrogel was synthesized from poly-γ-glutamic acid and polyethylene glycol. The shearmodulus G of the hydrogel has a steep dependence ofthe polymer volume fraction Φ2 as G ~Φ21.5±0.2.Diffusion coefficients of model protein release fromthe hydrogel could be controlled between 10?9 to 10?11cm2/s by altering the protein loading conditions.