Stable biodegradable, high water absorbable γ-polyglutamic acid hydrogel by 3-dimensional cross-linking and its preparation method

摘要

The present invention relates to a method for the production of a stable biodegradable, high water absorbable γ-polyglutamic acid (γ-PGA) hydrogel by directly cross-linking(A) a γ-polyglutamic acid (γ-PGA), a γ-polyglutamate, or a mixture thereof, and optionally a polysaccharide containing a carboxylic and/or carboxylate group, an amino acid, or a mixture thereof; and/or(B) a microbial culture broth containing a γ-polyglutamic acid (γ-PGA), a γ-polyglutamate, or a mixture thereof, and optionally a polysaccharide containing a carboxylic and/or carboxylate group, an amino acid, or a mixture thereof, with a cross-linker comprising a compound having three or more functional groups or a mixture of a compound having three or more functional groups and a compound having two functional groups,wherein each of the functional groups can react with a carboxylic group (—COOH), carboxylate group (—COO⁻), aldehyde group (—CHO), hydroxyl (—OH), carbonyl group (—CO), sulfone group (—SO₂), amino group (—NH₂) or nitro group (—NO₂), or a mixture thereof. The present invention further relates to a stable biodegradable, high water absorbable γ-polyglutamic acid (γ-PGA) hydrogel and its uses.