PEG-Containing Poly(ether-anhydride) Nanoparticles Rapidly Traverse Mucus Barriers

摘要

Mucus poses a difficult transport barrier for aerosolizedparticles aimed at the epithelia of the cystic fibrotic (CF)lung. Nanoparticles formulated from a di-blockcopolymer of poly(sebacic acid) and poly(ethylene)glycol (PSA-PEG) diffuse ~1000-fold more rapidly thansimilar-sized polystyrene particles in CF mucus andgreater than 80% of PSA-PEG particles are non-adhesivewith mucus.