A NEW GASTRORETENTIVE FORMULATION IN THE TREATMENT OF HELICOBACTER PYLORI

摘要

The purpose of this study was to design floating -bioadhesive microspheres containing acetohydroxamic acid (AHA) as a potent urease inhibitor whereas urease plays an important role in the colonization of Helicobacter pylori (H. pylori) (1). They were characterized for particle size, drug content, drug release, in vitro and in vivo floating studies (x-ray), in vitro bioadhesive property etc. From the in vitro studies, it was revealed that these formulations enhance the gastric residence time. The in vitro growth inhibition studies with isolated H. pylori cell culture proved that the floating-bioadhesive microspheres target H. pylori infected sites more effectively and could serve to optimize monotherapy of H. pylori based infections.