Application of physiologically based pharmacokinetic (PBPK) modeling to predict the distribution of trichloroethylene in different tissues of young male rats

摘要

Historically, the use of physiologically based pharmacokinetic models has been shown to be a valuable tool in providing information about xenobiotics entering into the body. The mass transport equations take into account physico-chemical andbiochemical parameters, and the resulting model can provide insights into the mechanisms of distribution for a given chemical. Such information may be related to the following: time-course for distribution and elimination, estimation of the effects ofphysiological parameters on tissue concentration and prediction of toxicokinetics of chemicals across various species by allo-metric scaling.