Intelligent control of the production process for l-isoleuine fermentation

摘要

The ability to supervise and control a highly non-linear and time variant bioprocess is of considerable importance to the biotechnological industries that are continually striving to obtain higher yields and improved uniformity of production. A distributed control system for L-isoleuine fermentation process is introduced in this paper. The structure of this system is composed of two hierarchical levels providing clear distribution of system functions. The standard sets of control tasks, such as measurement, filtration, data acquisition, control, etc., are entrusted to the lower level. The higher level represents an artificial intelligence system. The development and application of a real-time knowledge-based system to provide supervisory control of fed-batch bioprocesses is presented. The system performs sensor validation, fault detection and diagnosis and incorporates relevant expertise and experience drawn from both bioprocess engineering and control engineering domains.